In this episode, Homer, Reverend Lovejoy, and Apu Nahasapeemapetilon receive a letter from Moe stating that he will steal one of their wives. The three get together and try to remember intimate moments between Moe and their wives.

The episode was written by Stephanie Gillis and directed by Matthew Nastuk and guest stars Don Pardo as himself. The main plot of the episode is a parody of A Letter to Three Wives. It is the third episode after season 19's "Mona Leaves-a" and season 20's "Four Great Women and a Manicure" to air on Mother's Day and be centered around mothers and women. "Moe Letter Blues" received positive reviews from critics and was viewed by 5.660 million households according to the Nielsen Media Research.