In the episode, Marge and a group called the "Charity Chicks" pose for a history-oriented calendar in hopes of raising money for charity, but Marge becomes the talk of the town due to the erotic poses she made after a few drinks of red wine. Meanwhile, Carl is chosen as the newest supervisor at the Springfield Nuclear Power Plant, and hires Homer to be his personal assistant.

The episode was written by Tim Long and directed by Nancy Kruse. It was broadcast soon after the character Marge had appeared on the cover of Playboy, though there was no connection between the episode and the cover; the idea for the episode was conceived first, and Marge's appearance was due to an unrelated offer from Playboy. Since airing, "The Devil Wears Nada" has received mixed reviews from television critics.